Inspired by the life and adventures of the author's great-great grandmother, Betty Zane tells the story of the last battle of the American Revolution, in which the heroine was a young, spunky, and beautiful frontier girl named Betty Zane. In "The Last Trail", a woman is kidnapped from Fort Henry by a band of renegades and hostile Ohio Valley Indians, and Lewis Wetzel and Jonathan Zane set out in pursuit, with little hope of survival. Finally, in "The Spirit of the Border", Lewis Wetzel must single-handedly save Fort Henry, armed only with his long rifle and knife.