This practical manual covers the basic principle of care poisoned patients including elimination methods, supportive care, talking to relatives and use of the toxicology laboratory. It details practical instructions on care of patients with specific common and/or serious overdoses; for other overdoses, sufficient background is given to allow for appropriate management. It is equally important to know which substances are harmless to avoid unnecessary intervention and a section on non-hazardous agent is included. The final section covers the practical procedures of care and treatment especially when the caused agent may not have been identified.